In patients with schizophrenia, consent postmortem for organ donation for transplantation and research is usually obtained from relatives. By means of a questionnaire, the authors investigate whether patients with schizophrenia would agree to family members making such decisions for them as well as compare decisions regarding postmortem organ transplantation and brain donation between patients and significant family members. Study results indicate while most patients would not agree to transplantation or brain donation for research, a proportion would agree. Among patients who (...) declined organ donation for transplantation or brain research, almost half of family members would have agreed to brain donation for research and over 40% to organ transplantation. Male relatives are more likely to agree to organ donation from their deceased relatives for both transplantation and research. The authors argue that it is important to respect autonomy and interests of research subjects even if mentally ill and even if no longer living. Consent may be assisted by appropriate educational interventions prior to patient death. (shrink)

While the objects of olfaction are intuitively individuated by reference to the ordinary objects from which they arise, this intuition does not accurately capture the complex nature of smells. Smells are neither ordinary three-dimensional objects, nor Platonic vapors, nor odors. Rather, smells are the molecular structures of chemical compounds within odor plumes. Molecular Structure Theory is offered as an account of smells, which can explain the nature of the external object of olfactory perception, what we experience as olfactory objects, and (...) what determines the olfactory quality of smells by which we can demarcate the spatiotemporal boundaries of smells. (shrink)

Quality-space theory (QST) explains the nature of the mental qualities distinctive of perceptual states by appeal to their role in perceiving. QST is typically described in terms of the mental qualities that pertain to color. Here we apply QST to the olfactory modalities. Olfaction is in various respects more complex than vision, and so provides a useful test case for QST. To determine whether QST can deal with the challenges olfaction presents, we show how a quality space (QS) could be (...) constructed relying on olfactory perceptible properties and the olfactory mental qualities then defined by appeal to that QS of olfactory perceptible properties. We also consider how to delimit the olfactory QS from other modalities. We further apply QST to the role that experience plays in refining our olfactory discriminative abilities and the occurrence of olfactory mental qualities in non-conscious olfactory states. QST is shown to be fully applicable to and useful for understanding the complex domain of olfaction. (shrink)

We are immersed within an odorous sea of chemical currents that we parse into individual odors with complex structures. Odors have been posited as determined by the structural relation between the molecules that compose the chemical compounds and their interactions with the receptor site. But, naturally occurring smells are parsed from gaseous odor plumes. To give a comprehensive account of the nature of odors the chemosciences must account for these large distributed entities as well. We offer a focused review of (...) what is known about the perception of odor plumes for olfactory navigation and tracking, which we then connect to what is known about the role odorants play as properties of the plume in determining odor identity with respect to odor quality. We end by motivating our central claim that more research needs to be conducted on the role that odorants play within the odor plume in determining odor identity. (shrink)

Mental Imagery, whereby we experience aspect of a perceptual scene or perceptual object in the absence of direct sensory stimulation is ubiquitous. Often the existence of mental imagery is demonstrated by asking one’s reader to volitionally generate a visual object, such as closing ones eyes and imagining an apple. However, mental imagery also arises in auditory, tactile, interoceptive, and olfactory cases. A number of influential philosophical theories have attempted to explain mental imagery in terms of belief-based forms of representation using (...) the Dependence Thesis, dependence upon means of access, such as enactivism, or in terms of the similarity of content with perceptual processing. The focus of this paper concerns the later approach and in particular assessing if Nanay’s promissory note that his theory is applicable to modalities other than vision, such as smell, seems likely to be of theoretical tender. The thesis argued for in this paper is that olfactory imagery exists and is best accounted for by considering it as a type of perceptual processing with a unique representational format relative to the olfactory perceptual modality. The paper concludes by summarizing the applicability of Nanay’s theory of mental imagery for olfaction and suggests some further issues that arise when transitioning to multi-modal mental imagery. (shrink)

The notorious difficulty of Heidegger's post-Second World War discussions of 'the gods', along with scholarly disagreement about the import of those discussions, renders that body of work an unlikely place to look for a substantive theory of religion. The thesis of this article is that, contrary to these appearances, Heidegger's later works do contain clues for developing such a theory. Heidegger's concerns about the category of 'religion' are addressed, and two recent attempts to 'de-mythologize' Heidegger's 'gods' are examined and criticized. (...) The paper concludes by outlining four substantial contributions that Heidegger's later work makes to a phenomenological account of religion. (shrink)

J. G. Fichte (1762–1814) articulates and defends a conception of autonomy as rational self-identification. This paper reconstructs this conception and examines various difficulties recognized by Fichte during the earliest phases of his career (1780s–1790s), with the heterogeneity of natural drives and freedom as the principal threat. Theoretically, this heterogeneity is overcome for Fichte by his deduction of the compound nature of humanity as a condition of rational agency. But, from the standpoint of the deliberating agent herself, this deduction is not (...) sufficient. The harmony of nature and freedom is, for Fichte, a desideratum of practical rationality, and so must be addressed as such. Fichte's argument at this point is that a further perspective on oneself must be at least implicit in the moral outlook of a deliberating agent in order for this harmony to be attained on a practical level. This is because the harmony that is achieved at the deliberative level is occasional, temporary, and fundamentally uncertain. The required perspective turns out to be religious faith, the idea that the ‘infinite task’ of morality is eternally realized in divine reason, or that there is a ‘moral world order’ in which nature and freedom are reconciled. (shrink)

Theoretical Perspective on Smell is the first collection of scholarly articles to be devoted exclusively to philosophical research on olfaction. The essays, published here for the first time, bring together leading theorists working on smell in a format that allows for deep engagement with the emerging field, while also providing those new to the philosophy of smell with a resource to begin their journey. The volume’s 14 chapters are organized into four parts: -/- I. The Importance and Beauty of Smell (...) II. Smell in Time and Space III. What We Perceive through Smell IV. Smell and Other Senses -/- The collection solidifies the area as an important emerging branch of perceptual philosophy by presenting the cutting edge research being done by innovative early career researchers, as well as by those more senior and established within the field. -/- Table of Contents 1. Introduction Andreas Keller and Benjamin Young -/- Part I: The Importance and Beauty of Smell -/- 2. The Role of Smell in Consciousness Barry C. Smith -/- 3. The metacognitive gap: Why we both trust and mistrust our sense of smell Ophelia Deroy -/- 4. Perfumes and the Aesthetic Appreciation of Nature Chiara Brozzo -/- 5. Aesthetics, Olfaction, & Environment Michael Aaron Lindquist -/- Part II: Smell in Time and Space -/- 6. Smell and the Space Between Us Clare Batty -/- 7. The Temporal Structure of Olfactory Experience Keith A. Wilson -/- Part III: What We Perceive through Smell -/- 8. How Biology Perceives Chemistry: A Causal Analysis of the Stimulus in Olfaction and its Implications for Scientific and Philosophical Theorizing Ann-Sophie Barwich -/- 9. The Accuracy Conditions of Olfactory Perception Andreas Keller -/- 10. Maybe We Don't Smell Molecular Structure Benjamin D. Young -/- 11. Stuff & Nonsense: Against Mizrahi on Olfaction Harry Sherwood -/- 12. The Layering of Smell William G. Lycan -/- Part IV: Smell and the Other Senses -/- 13. From Odors to Flavors: Perceptual organization in the chemical senses Becky Millar -/- 14. Seeing and hearing flavors Błażej Skrzypulec -/- 15. Smelling Gustatory Qualities Louise Richardson. (shrink)

Sheds new light on Heidegger's early theological development.

Throughout his long and controversial career, Martin Heidegger developed a substantial contribution to the phenomenology of religion. In Heidegger's Phenomenology of Religion, Benjamin D. Crowe examines the key concepts and developmental phases that characterized Heidegger's work. Crowe shows that Heidegger's account of the meaning and structure of religious life belongs to his larger project of exposing and criticizing the fundamental assumptions of late modern culture. He reveals Heidegger as a realist through careful readings of his views on religious attitudes (...) and activities. Crowe challenges interpretations of Heidegger's early efforts in the phenomenology of religion and later writings on religion, including discussions of Greek religion and Hölderlin's poetry. This book is sure to spark discussion and debate as Heidegger's work in religion and the philosophy of religion becomes increasingly important to scholars and beyond. (shrink)

We sketch the ideas behind the use of chromatic numbers in establishing descriptive set-theoretic dichotomy theorems.

The Ethiosemitic verb hlw ‘to be present’ is strange in three regards: it shows an unusual alternation between -o and -awa in Classical Ethiopic; it is formally Perfect, but used in the present tense; and it has no verbal cognates in other branches of Semitic. This is because it is originally not a Perfect, but a presentative particle, to be connected with other Semitic presentatives reflecting *hallaw. Due to the leveling of the second-person object suffixes to the Perfect endings in (...) Ethiosemitic, suffixed presentative forms like hallo-ka could be reanalyzed as consisting of a verbal stem hallo- and a subject ending -ka. Other forms of the paradigm, including the 3M.SG Perfect hallaw-a, were then created by analogy with III-w 02-stem verbs like fannawa ‘to send’. (shrink)

Recent scholars have examined the important role of English Deism in the formation of a modern naturalistic approach to the study of human religiosity. Despite the volume of important studies of various aspects of his thought, the role of Francis Hutcheson (1694?1746) in this development has been overlooked. The aim of this paper is to show how Hutcheson develops his own account of the origins of religion, consonant with his more well-known theories in aesthetics and moral philosophy, that diverges sharply (...) from the then-prevailing Deist views. Hutcheson pioneers a psychological account of religion that anticipates the work of nineteenth- and twentieth-century scholars in important ways. At the same time, Hutcheson incorporates his account of the origins of religion into an overall vision of human flourishing. (shrink)

Several recent research findings have implicated brain-derived neurotrophic factor (BDNF) as a mediator of neuronal plasticity. The BDNF gene is under extensive epigenetic regulation, which modulates how much or how little environmental experiences become encoded within neurons and neural circuits. Future scientific progress within the postgenomic paradigm requires elucidation of the functional trajectory in neogenetic and environment interactions.

Infant language learners are faced with the difficult inductive problem of determining how new words map to novel or known objects in their environment. Bayesian inference models have been successful at using the sparse information available in natural child-directed speech to build candidate lexicons and infer speakers’ referential intentions. We begin by asking how a Bayesian model optimized for monolingual input generalizes to new monolingual or bilingual corpora and find that, especially in the case of the bilingual input, the model (...) shows a significant decrease in performance. In the next experiment, we propose the ME Model, a modified Bayesian model, which approximates infants’ mutual exclusivity bias to support the differential demands of monolingual and bilingual learning situations. The extended model is assessed using the same corpora of real child-directed speech, showing that its performance is more robust against varying input and less dependent than the Intentional Model on optimization of its parsimony parameter. We argue that both monolingual and bilingual demands on word learning are important considerations for a computational model, as they can yield significantly different results than when only one such context is considered. (shrink)

In this paper, I offer a third way in debates over the scope of phenomenal consciousness, in the form of a novel synthesis of liberal and conservative introspective observations. My primary claim is that at least some liberal observations arise due to the existence of a heretofore unrecognized type of phenomenal concepts, liberal phenomenal concepts, while conservative observations arise by virtue of the nonexistence of at least some types of liberal phenomenal contents. Liberal phenomenal concepts, when deployed in direct introspection (...) on phenomenal consciousness, misrepresent consciousness as including high-level, liberal contents. The misattribution of these contents to consciousness is partly defeasible, however: by using a more methodical, stringent heuristic for cataloging the introspected contents of consciousness, it is possible to note the nonexistence of liberal phenomenal contents. Thus, at least in some cases, conservatives are right and liberals are wrong about the scope of phenomenal consciousness. However, liberals have picked up on something conservatives have missed: an inaccurate introspective appearance caused by liberal phenomenal concepts. The structure of the paper is as follows. I begin by defending the faithfulness to introspection of liberal and conservative observations in the context of the debate over the existence of cognitive phenomenology. I then show how liberal phenomenal concepts can explain these observations, and discuss three jointly sufficient conditions whose collective truth serves to establish that a type of liberal content is misattributed to phenomenal consciousness by such concepts. Before concluding, I briefly consider an explanation for why liberal phenomenal concepts might exist. (shrink)

The purpose of this study is to provide a detailed exposition of Heidegger's conception of philosophy as "destruction [Destruktion]." My thesis is that the ultimate motivation for engaging in this practice of Destruktion is the value of an "authentic" way of life. That is, "destruction" is a philosophical practice that aims at cultivating authenticity as a concrete possibility for individual men and women. I argue for this claim by first of all examining the theological sources for Heidegger's notion of "destruction," (...) with a particular focus on Luther. Second, I provide a detailed exposition of the development of "destruction" in Heidegger's work from the 1920's, and of the ideas intimately linked with it. ;In Chapter One, I undertake to clarify Heidegger's philosophical position on the importance of religion and theology not only for Western intellectual history as a whole, but also for his own idiosyncratic philosophical project. In Chapter Two I explore the role that his study of Luther played in the development of Heidegger's conception of philosophy as "destruction." In Chapter Three, I lay some necessary groundwork for my later discussion by examining Heidegger's conception of human selfhood. In Chapter Four, I undertake to give a thorough account of Heidegger's conception of an "inauthentic" way of life. In Chapter Five, I examine Heidegger's views about the way public discourse, particularly intellectual discourse, is oftentimes complicit in an inauthentic way of life. In Chapter Six, I locate Heidegger's conception of authenticity within the tradition of Romantic personalism, and show how he investigates the roots of this tradition in primitive Christianity. In Chapter Seven, I present an explication of Heidegger's conception of an "authentic life" by focusing on his works before and including Being and Time. Having laid the groundwork for understanding the meaning of "destruction" in Chapters One through Seven, I begin an explicit examination of the nature of Heidegger's conception of philosophy in Chapter Eight. Chapter Nine is the culmination of my argument, in which I focus on the idea of "destruction," and show that it is everywhere linked with Heidegger's ideal of an authentic way of life. (shrink)

Fichte's most influential presentation of his Wissenschaftslehre, which coincides with his tenure at Jena, has, ironically, been subjected to incredulity, misunderstanding, and outright hostility. In a recent essay, noted scholar Daniel Breazeale has undertaken to challenge this history of neglect and misunderstanding by pointing to the significance of striking passages from Fichte's writings in which he asserts that his philosophical system is fictional. At the same time, Breazeale also notes some of the tensions between this fictionalist reading of the Jena (...) Wissenschaftslehre and Fichte's equally forceful insistence on the reality of his system. In this essay, I argue that these two sides of Fichte's conception of his philosophy can, in fact, be reconciled by looking more carefully at distinctions that Fichte himself draws between realities, philosophical fictions, and mere fabrications. What results is a clearer picture of Fichte's conception of transcendental philosophy that builds upon Breazeale's valuable insights. (shrink)

(2008). On ‘The religion of the visible Universe’: Novalis and the pantheism controversy. British Journal for the History of Philosophy: Vol. 16, No. 1, pp. 125-146.

Mind &Language, Volume 35, Issue 1, Page 90-114, February 2020.

Science museums aim to provide educational experiences for both children and adults. To achieve this goal, museum displays must convey scientifically-relevant relationships, such as the similarities that unite members of a natural category, and the connections between scientific models and observable objects and events. In this paper, we explore how research on comparison could be leveraged to support learning about such relationships. We describe how museum displays could promote educationally-relevant comparisons involving natural specimens and scientific models. We also discuss how (...) these comparisons could be supported through the design of a display—in particular, by using similarity, space, and language to facilitate relational thinking for children and their adult companions. Such supports may be pivotal given the informal nature of learning in museums. (shrink)

There is consensus within the chemosciences that olfactory perception is of the molecular structure of chemical compounds, yet within philosophical theories of smell there is little agreement about the nature of smell. The paper critically assesses the current state of debate regarding smells within philosophy in the hopes of setting it upon firm scientific footing. The theories to be covered are: Naïve Realism, Hedonic Theories, Process Theory, Odor Theories, and non-Objectivist Theories. The aforementioned theories will be evaluated based on their (...) explanations of the (a) the olfactory quality of a smell, (b) smells as distal entities, and (c) our experience of smells as intentional objects. The paper concludes with a defense of Molecular Structure Theory that demonstrating its superiority in accounting for each of these three aspects of smell. (shrink)

We perceive smells as perduring complex entities within a distal array that might be conceived of as smellscapes. However, the philosophical orthodoxy of Odor Theories has been to deny that smells are perceived as having a distal location. Recent challenges have been mounted to Odor Theories’ veracity in handling the timescale of olfactory perception, how it individuates odors as a distal entities, and their claim that olfactory perception is not spatial. The paper does not aim to dispute these criticisms. Rather, (...) what will be shown is that Molecular Structure Theory, a refinement of Odor Theory, can be further developed to handle these challenges. The theory is further refined by focusing on distal perception that requires considering the perceptual object as mereologically complex persisting odor against a background scene conceived of as a smellscape. What will be offered is an expansion of Molecular Structure Theory to account for distal smell perception within natural environments. (shrink)

The mass killings, large-scale gang rape and large-scale expulsion of the Rohingyas from Myanmar constitute one of the most repugnant world events in recent years. This article addresses the question of whether armed humanitarian intervention would have been morally permissible to protect the Rohingyas. It approaches the question from the perspective of the jus ad bellum criteria of just war theory. This approach does not yield a definitive answer because knowing whether certain jus ad bellum conditions might have been satisfied (...) is difficult to judge without detailed knowledge of military intelligence assessments. Nevertheless, I argue that there was just cause for intervention according to both liberal and communitarian perspectives; that legitimate authority in the form of United Nations Security Council authorization would not have been morally necessary; that it is doubtful whether permissible intervention would have required humanitarian intent; that in late August 2017, intervention might well have been a last resort, but that morally relevant facts suggest intervention might have been disproportionate and lacked a reasonable chance of success, such that, all things considered, it would have perhaps been impermissible. -/- (Free access via third external link). (shrink)

This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1961.

Studies that examine both compositional criticism and the history of exegesis can uncover continuity between pre-biblical documents and later religious expression. Two examples are used to demonstrate such trajectories and to explore their interest to a contemporary religious person. Documents underlying descriptions of lawgiving at Sinai in the book of Exodus and texts relating to the eschaton in the book of Isaiah are shown to have deep affiliations with ancient, medieval, and modern trends in Jewish thought which are barely noticeable (...) without source critical analysis. (shrink)

The Patient Self Determination Act of 1991 brought much needed attention to the importance of advance care planning and surrogate decision-making. The purpose of this law is to ensure that a patient’s preferences for medical care are recognized and promoted, even if the patient loses decision-making capacity. In general, patients are presumed to have DMC. A patient’s DMC may come under question when distortions in thinking and understanding due to illness, delirium, depression or other psychiatric symptoms are identified or suspected. (...) Physicians and other healthcare professionals working in hospital settings where medical illness is frequently comorbid with depression, adjustment disorders, demoralization and suicidal ideation, can expect to encounter ethical tension when medically sick patients who are also depressed or suicidal request do not resuscitate orders. (shrink)

Amodal completion is the representation of those parts of the perceived object that we get no sensory stimulation from. While amodal completion is rife and plays an essential role in all sense modalities, philosophical discussions of this phenomenon have almost entirely been limited to vision. The aim of this paper is to examine in what sense we can talk about amodal completion in olfaction. We distinguish three different senses of amodal completion – spatial, temporal and feature-based completion – and argue (...) that all three are present and play a significant role in olfaction. (shrink)

Olfactory perception provides a promising test case for enactivism, since smelling involves actively sampling our surrounding environment by sniffing. Smelling deploys implicit skillful knowledge of how our movement and the airflow around us yield olfactory experiences. The hybrid nature of olfactory experience makes it an ideal test case for enactivism with its esteem for touch and theoretical roots in vision. Olfaction is like vision in facilitating the perception of distal objects, yet it requires us to breath in and physically contact (...) the sensory object in a manner similar to touch. The paper offers an analysis of the central theoretical components of enactivism, whose soundness and empirical viability are tested using the empirical literature on sniffing. It will be shown that even if sniffing is an essential component of olfaction, the motoric component is not necessary for perceiving smells, which is contrary to the most crucial tenet of enactivism. Thus, the paper concludes that the theory cannot account for olfactory perception. (shrink)

The chapter unfolds in the following sections. The first section exam- ines the reasons for claiming that olfactory perception is spatially unstruc- tured and our experience of smells has an abstract structure. The second section elucidates the further arguments that olfaction cannot generate figure-ground segregation. The third section assesses the conclusion that olfactory perception and experience cannot solve the MPP. Following the overview of the many problems inherent to distal olfactory percep- tion, MST will be introduced as an alternative perspective (...) that allows for figure-ground segregation and perceiving multiple olfactory objects within an array. The chapter then concludes by replying to the shared argument that olfactory distal perception does not have the requisite res- olution to resolve the many properties problem. (shrink)

We give classical proofs, strengthenings, and generalizations of Lecomte’s characterizations of analytic ω-dimensional hypergraphs with countable Borel chromatic number.

We show that if add(null) = c, then the globally Baire and universally measurable chromatic numbers of the graph of any Borel function on a Polish space are equal and at most three. In particular, this holds for the graph of the unilateral shift on [N]N, although its Borel chromatic number is N₀. We also show that if add(null) = c, then the universally measurable chromatic number of every treeing of a measure amenable equivalence relation is at most three. In (...) particular, this holds for "the" minimum analytic graph G₀ with uncountable Borel (and Baire measurable) chromatic number. In contrast, we show that for all κ ∈ {2, 3...., N₀. c}, there is a treeing of E₀ with Borel and Baire measurable chromatic number κ. Finally, we use a Glimm—Effros style dichotomy theorem to show that every basis for a non-empty initial segment of the class of graphs of Borel functions of Borel chromatic number at least three contains a copy of (R<N, ⊇). (shrink)

Alexander Nehamas and others have recently attempted to revive a conception of ethics that is centered on self-formation and the values of aesthetic coherence. This conception faces several difficulties, including the lack of fit between models of aesthetic coherence in literary works and individual lives and an absence of determinate content. The argument of this paper is that both of these defects are absent from the work of one of the earliest and most vocal exponents of this conception of ethics, (...) Friedrich von Hardenberg (1772–1801), better known by his pseudonym “Novalis”. The paper begins by reviewing the growing consensus among scholars that Novalis makes a serious contribution to philosophy, and by pointing out the lack of attention paid to his moral philosophy. His conception of moral life as an infinite process of approximation the archetypal unity of the divine is then explicated in detail. Particular attention is paid to the manner in which his model of moral life and conception of aesthetic coherence avoids some of the difficulties faced by more recent theorists. (shrink)

The nineteenth century was one of the most remarkable periods in the history of philosophy and a period of great intellectual, social and scientific change. Challenging philosophical thought of earlier centuries, it caused shock waves that lasted well into the twentieth century. The Nineteenth Century Philosophy Reader is an outstanding anthology of the great philosophical texts of the period and the first of its kind for many years. In presenting many of the major ideas expounded by philosophers of the nineteenth (...) century themselves, it provides the reader with a comprehensive account of this extremely important and fertile period. Carefully selected extracts from the following philosophers are included, providing a solid introduction to the most fundamental arguments and insights of each thinker: Kant Fichte Schelling Hegel British Idealism Schopenhauer Marx and Engels Kierkegaard Nietzsche William James. In addition to an introduction by the editor, a key feature of the reader is a specially commissioned introduction to each part by leading scholars in the field, placing the extracts in philosophical and historical context. The Nineteenth Century Philosophy Reader is an ideal anthology for anyone seeking to engage with and learn about this important period. As well as students of nineteenth-century philosophy it will also be of interest to those in related fields such as literature, religion and social and political theory. (shrink)

Qualitative-consciousness arises at the sensory level of olfactory processing and pervades our experience of smells to the extent that qualitative character is maintained whenever we are aware of undergoing an olfactory experience. Building upon the distinction between Access and Phenomenal Consciousness the paper offers a nuanced distinction between Awareness and Qualitative-consciousness that is applicable to olfaction in a manner that is conceptual precise and empirically viable. Mounting empirical research is offered substantiating the applicability of the distinction to olfaction and showing (...) that olfactory qualitative-consciousness can occur without awareness, but any olfactory state that we are aware of being in is always qualitative. Evidence that olfactory sensory states have a qualitatively character in the absence of awareness derives from research on mate selection, the selection of social preference for social interaction and acquaintances, as well as the role of olfactory deficits in causing affective disorders. Furthermore, the conservation of secondary processing measures of olfactory valence during olfactory imagery experiments provides verification that olfactory awareness is always qualitatively conscious—all olfactory consciousness smells phenomenal. (shrink)

Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 diabetes, or neurological disorders. However, it is unclear to what extent a perturbation of pathways regulated by both the circadian clock and microbiota is involved in the development of these disorders. It is speculated that these perturbations are associated with impaired growth hormone (GH) secretion and (...) sexual development. The GH axis is a broadly neglected pathway and could be the main converging point for the interaction of both circadian clock and microbiota. Here, the links between the circadian clock and microbiota are reviewed. Finally, the effects of chronodisruption and dysbiosis on physiology and pathology are discussed and it is speculated whether a common deregulation of the GH pathway could mediates those effects. (shrink)